Matthew Perry dies due to ‘severe effects of ketamine’

Matthew Perry died from “the acute effects of ketamine,” according to the toxicology report from the Los Angeles County Medical Examiner’s Office. The exact method of intake is unknown. Contributing factors in the “Friends” actor’s death included drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder). The manner of death was ruled an accident.

Perry had been undergoing ketamine infusion therapy prior to his death, reportedly for depression and anxiety. The toxicology report adds: “At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression.”

Sources Matthew Perry’s Cause of Death Revealed as ‘Acute Effects of Ketamine’